Basically if Big Head decides that Wade reminds him of a burger patty, then he's on a bun and that's all she wrote
The conceit of the Mask however, and this is as true in the comics as it was everywhere else, is that if the wearer decides to remove it themselves then it's over for them
And they ALWAYS get tricked or decide to remove it without fail because becoming Big Head is a strain on the psyche
Oh, why must I tell 'em again?
What must I tell 'em, my friend?
That we are born into sin
And we are worshiping murderers
Nothing but evil duplicitous men
I know you heard of 'em all
We should just murder 'em all
We should just murder and ball
We dance on the ruins we looting from all of they palace's walls