Warner Bros. has just confirmed that veteran character actress Carol Ann Susi, who is best known for her role as the unseen and bellowing yet beloved Mrs. Wolowitz on CBS’s The Big Bang Theory, has died after a brief battle with an aggressive cancer.

Warner Bros. issued the following statement from Warner Bros. Television, CBS and The Big Bang Theory Executive Producers Chuck Lorre, Seven Molaoro and Bill Prady: "The Big Bang Theory family has lost a beloved member today with the passing of Carol Ann Susi, who hilariously and memorably voiced the role of Mrs. Wolowitz. Unseen by viewers, the Mrs. Wolowitz character became a bit of a mystery throughout the show’s eight seasons. What was not a mystery, however, was Carol Ann’s immense talent and comedic timing, which were on display during each unforgettable appearance. In addition to her talent, Carol Ann was a constant source of joy and kindness to all. Our thoughts and deepest condolences are with her family during this time, and we will miss her greatly." (...) Dozens of TV guest appearances followed, including Cheers; Doogie Howser, M.D.; Mad About You; Just Shoot Me; Seinfeld and Six Feet Under, to name a few.