Basically if Big Head decides that Wade reminds him of a burger patty, then he's on a bun and that's all she wrote
The conceit of the Mask however, and this is as true in the comics as it was everywhere else, is that if the wearer decides to remove it themselves then it's over for them
And they ALWAYS get tricked or decide to remove it without fail because becoming Big Head is a strain on the psyche
Too deep in yearning we need
something to hold, and something to keep
Innocent eyes could not realize
the meaning of "destiny"
But someday I promise that
you’ll start to notice what’s there on your shoulders someday -
Wings that are strong,
they will guide you along to the future that holds your fate!
Let me tell you a cruel angel’s thesis -
Flying high from the window, finding egress
There is something betraying all my memories,
burning pathos, emotion overwhelming!